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Beyond this the main trick of science is to really think of something: the shape of clouds and their occasional sharp bottom edges at the same altitude everywhere in the sky; the formation of a dewdrop on a leaf; the origin of a name or a word-Shakespeare, say, or “philanthropic”; the reason for human social customs-the incest taboo, for example; how it is that a lens in sunlight can make paper burn; how a “walking stick” got to look so much like a twig; why the Moon seems to follow us as we walk; what prevents us from digging a hole down to the center of the Earth; what the definition is of “down” on a spherical Earth; how it is possible for the body to convert yesterday’s lunch into today’s muscle and sinew; or how far is up-does the universe go on forever, or if it does not, is there any meaning to the question of what lies on the other side? Some of these questions are pretty easy. Others, especially the last, are mysteries to which no one even today knows the answer. They are natural questions to ask. Every culture has posed such questions in one way or another. Almost always the proposed answers are in the nature of “Just So Stories,” attempted explanations divorced from experiment, or even from careful comparative observations.

But the scientific cast of mind examines the world critically as if many alternative worlds might exist, as if other things might be here which are not. Then we are forced to ask why what we see is present and not something else. Why are the Sun and the Moon and the planets spheres? Why not pyramids, or cubes, or dodecahedra? Why not irregular, jumbly shapes? Why so symmetrical, worlds? If you spend any time spinning hypotheses, checking to see whether they make sense, whether they conform to what else we know, thinking of tests you can pose to substantiate or deflate your hypotheses, you will find yourself doing science. And as you come to practice this habit of thought more and more you will get better and better at it. To penetrate into the heart of the thing-even a little thing, a blade of grass, as Walt Whitman said-is to experience a kind of exhilaration that, it may be, only human beings of all the beings on this planet can feel. We are an intelligent species and the use of our intelligence quite properly gives us pleasure. In this respect the brain is like a muscle. When we think well, we feel good. Understanding is a kind of ecstasy.

But to what extent can we really know the universe around us? Sometimes this question is posed by people who hope the answer will be in the negative, who are fearful of a universe in which everything might one day be known. And sometimes we hear pronouncements from scientists who confidently state that everything worth knowing will soon be known-or even is already known-and who paint pictures of a Dionysian or Polynesian age in which the zest for intellectual discovery has withered, to be replaced by a kind of subdued languor, the lotus eaters drinking fermented coconut milk or some other mild hallucinogen. In addition to maligning both the Polynesians, who were intrepid explorers (and whose brief respite in paradise is now sadly ending), as well as the inducements to intellectual discovery provided by some hallucinogens, this contention turns out to be trivially mistaken.

Let us approach a much more modest question: not whether we can know the universe or the Milky Way Galaxy or a star or a world. Can we know, ultimately and in detail, a grain of salt? Consider one microgram of table salt, a speck just barely large enough for someone with keen eyesight to make out without a microscope. In that grain of salt there are about 1016 sodium and chlorine atoms. This is a 1 followed by 16 zeros, 10 million billion atoms. If we wish to know a grain of salt, we must know at least the three-dimensional positions of each of these atoms. (In fact, there is much more to be known-for example, the nature of the forces between the atoms-but we are making only a modest calculation.) Now, is this number more or less than the number of things which the brain can know?

How much can the brain know? There are perhaps 1011 neurons in the brain, the circuit elements and switches that are responsible in their electrical and chemical activity for the functioning of our minds. A typical brain neuron has perhaps a thousand little wires, called dendrites, which connect it with its fellows. If, as seems likely, every bit of information in the brain corresponds to one of these connections, the total number of things knowable by the brain is no more than 1014, one hundred trillion. But this number is only one percent of the number of atoms in our speck of salt.

So in this sense the universe is intractable, astonishingly immune to any human attempt at full knowledge. We cannot on this level understand a grain of salt, much less the universe.

But let us look a little more deeply at our microgram of salt. Salt happens to be a crystal in which, except for defects in the structure of the crystal lattice, the position of every sodium and chlorine atom is predetermined. If we could shrink ourselves into this crystalline world, we would see rank upon rank of atoms in an ordered array, a regularly alternating structure-sodium, chlorine, sodium, chlorine, specifying the sheet of atoms we are standing on and all the sheets above us and below us. An absolutely pure crystal of salt could have the position of every atom specified by something like 10 bits of information. [1] This would not strain the information-carrying capacity of the brain.

If the universe had natural laws that governed its behavior to the same degree of regularity that determines a crystal of salt, then, of course, the universe would be knowable. Even if there were many such laws, each of considerable complexity, human beings might have the capability to understand them all. Even if such knowledge exceeded the information-carrying capacity of the brain, we might store the additional information outside our bodies-in books, for example, or in computer memories-and still, in some sense, know the universe.

Human beings are, understandably, highly motivated to find regularities, natural laws. The search for rules, the only possible way to understand such a vast and complex universe, is called science. The universe forces those who live in it to understand it. Those creatures who find everyday experience a muddled jumble of events with no predictability, no regularity, are in grave peril. The universe belongs to those who, at least to some degree, have figured it out.

It is an astonishing fact that there are laws of nature, rules that summarize conveniently-not just qualitatively but quantitatively-how the world works. We might imagine a universe in which there are no such laws, in which the 1080 elementary particles that make up a universe like our own behave with utter and uncompromising abandon. To understand such a universe we would need a brain at least as massive as the universe. It seems unlikely that such a universe could have life and intelligence, because beings and brains require some degree of internal stability and order. But even if in a much more random universe there were such beings with an intelligence much greater than our own, there could not be much knowledge, passion or joy.

Fortunately for us, we live in a universe that has at least important parts that are knowable. Our common-sense experience and our evolutionary history have prepared us to understand something of the workaday world. When we go into other realms, however, common sense and ordinary intuition turn out to be highly unreliable guides. It is stunning that as we go close to the speed of light our mass increases indefinitely, we shrink toward zero thickness in the direction of motion, and time for us comes as near to stopping as we would like. Many people think that this is silly, and every week or two I get a letter from someone who complains to me about it. But it is a virtually certain consequence not just of experiment but also of Albert Einstein’s brilliant analysis of space and time called the Special Theory of Relativity. It does not matter that these effects seem unreasonable to us. We are not in the habit of traveling close to the speed of light. The testimony of our common sense is suspect at high velocities.

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[1] Chlorine is a deadly poison gas employed on European battlefields in World War I. Sodium is a corrosive metal which burns upon contact with water. Together they make a placid and unpoisonous material, table salt. Why each of these substances has the properties it does is a subject called chemistry, which requires more than 10 bits of information to understand.