26. G. Hutter et al., “Long-term control of HIV by CCR5 delta32/delta32 stem-cell transplantation,” New England Journal of Medicine 360, (2009): 692–698, https://www.nejm.org/doi/full/10.1056/NEJMoa0802905.
27. F. Urnov, “AWESOME interview with Dr. Fyodor Urnov,” The Sangamo Domain (blog), December 12, 2015, http://sangamodomain.blogspot.com/2015/12/awesome-interview-with-dr-fyodor-urnov.html.
28. P. Tebas et al., “Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV,” New England Journal of Medicine 370, (2014): 901–910, https://www.nejm.org/doi/full/10.1056/nejmoa1300662.
29. Emily Mullin, “Back to the Future: Pre-CRISPR Systems are Driving Therapies to the Clinic,” Genetic Engineering & Biotechnology News, February 7, 2019, https://www.genengnews.com/insights/back-to-the-future-pre-crispr-systems-are-driving-therapies-to-the-clinic/.
30. CNBC, “Sangamo Biosciences CEO Edward Lanphier | Mad Money | CNBC,” YouTube video, 8:19, March 7, 2019, https://www.youtube.com/watch?v=c3dT1sH1PNM.
31. Brian Madeux quoted in M. Marchione, “US scientists try 1st gene editing in the body,” AP News, November 15, 2017, https://apnews.com/4ae98919b52e43d8a8960e0e260feb0a.
32. C. Hunter, “A rare disease in two brothers,” Journal of the Royal Society of Medicine 10, (1917): 104–116, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2018097/pdf/procrsmed00727-0110.pdf.
33. Sandy Macrae, Genome Editing summit, National Academy of Sciences, Washington, DC, August 13, 2019, https://vimeo.com/showcase/6229550/video/354892447.
34. B. Zeitler et al., “Allele-specific transcriptional repression of mutant HTT for the treatment of Huntington’s disease,” Nature Medicine 25, (2019): 1131–1142, https://www.nature.com/articles/s41591-019-0478-3.
35. Ed Rebar, “Genome Engineering,” (lecture, Keystone Symposium, Victoria, Canada, February 2019).
Chapter 9: Deliverance or Disaster
1. Anon, “Mount Hope geneticists get more milk from cows by selective breeding,” Life 5, 50–53 (1938).
2. J. A. Wolff and J. Lederberg, “An early history of gene transfer and therapy,” Human Gene Therapy 5, (1994): 469–480, https://www.liebertpub.com/doi/abs/10.1089/hum.1994.5.4-469.
3. Derek So, “The Use and Misuse of Brave New World in the CRISPR Debate,” CRISPR Journal 2, (2019): 316–323, https://www.liebertpub.com/doi/10.1089/crispr.2019.0046.
4. Jack Williamson, Dragon’s Island (New York: Simon & Schuster, 1951).
5. Francis Crick, letter to Michael Crick, March 15, 1953, Wellcome Library, https://wellcomelibrary.org/item/b1948799x.
6. J. D. Watson, correspondence: Letter to Max Delbruck, March 12, 1953, http://scarc.library.oregonstate.edu/coll/pauling/dna/corr/corr432.1-watson-delbruck-19530312-transcript.html.
7. Brenda Maddox, “DNA’s double helix: 60 years since life’s deep molecular secret was discovered,” Guardian, February 22, 2013, https://www.theguardian.com/science/2013/feb/22/watson-crick-dna-60th-anniversary-double-helix.
8. J. D. Watson and F. H. C. Crick, “Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid,” Nature 171, (1953):737–738, http://dosequis.colorado.edu/Courses/MethodsLogic/papers/WatsonCrick1953.pdf.
9. Brenda Maddox, “DNA’s double helix: 60 years since life’s deep molecular secret was discovered,” Guardian, February 22, 2013, https://www.theguardian.com/science/2013/feb/22/watson-crick-dna-60th-anniversary-double-helix.
10. Symposium held at Ohio Wesleyan University, Delaware, on April 6, 1963. The proceedings were published in The Control of Human Heredity and Evolution (1965).
11. S. E. Luria, The Control of Human Heredity and Evolution, ed. T. M. Sonneborn (New York: Macmillan, 1965).
12. E. M. Witkin, “Remembering Rollin Hotchkiss (1911–2004),” Genetics 170, (2005): 1443–1447, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1449782/.
13. R. Hotchkiss, The Control of Human Heredity and Evolution, ed. T. M. Sonneborn (New York: Macmillan, 1965).
14. R. Sinsheimer, “The End of the Beginning,” (lecture, Caltech, October 26, 1966). Excerpt in Human Nature (2019).
15. R. Sinsheimer, “The Prospect of Designed Genetic Change,” American Scientist XXXII, (1969): 8–13, http://calteches.library.caltech.edu/2718/1/genetic.pdf.
16. M. Nirenberg, “Will society be prepared?,” Science 157, (1967): 633, https://science.sciencemag.org/content/157/3789/633.
17. J. Lederberg, “Molecular biology, eugenics and euphenics,” Nature 198, (1963): 428–429, https://www.nature.com/articles/198428a0.pdf.
18. J. A. Wolff and J. Lederberg, “An early history of gene transfer and therapy,” Human Gene Therapy 5, (1994): 469–480, https://www.liebertpub.com/doi/abs/10.1089/hum.1994.5.4-469.
19. J. Lederberg, “DNA breakthrough points way to therapy by virus,” Washington Post, January 13, 1968, https://profiles.nlm.nih.gov/ps/access/BBABSP.pdf.
20. J. Lederberg, in J. A. Wolff and J. Lederberg, “An early history of gene transfer and therapy,” Human Gene Therapy 5, (1994): 469–480, https://www.liebertpub.com/doi/abs/10.1089/hum.1994.5.4-469.
21. N. A. Wivel and W. F. Anderson, “Human Gene Therapy: Public Policy and Regulatory Issues,” in The Development of Human Gene Therapy, ed. T. Friedmann (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1999), pp 671–689.
Chapter 10: The Rise and Fall of Gene Therapy
1. S. Rogers, “Shope papilloma virus: A passenger in man and its significance to the potential control of the host genome,” Nature 212, (1966): 1220–1222, https://www.nature.com/articles/2121220a0.