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Chapter 16: Breaking the Glass
1. Pam Belluck, “Gene-edited babies: What a Chinese scientist told an American mentor,” New York Times, April 14, 2019, https://www.nytimes.com/2019/04/14/health/gene-editing-babies.html.
2. He Jiankui, “Cold Spring Harbor Gene Editing Conference,” Science Net (blog), August 24, 2016, http://blog.sciencenet.cn/home.php?mod=space&uid=514529&do=blog&id=998292.
3. M. DeWitt et al., “Selection-free Genome Editing of the Sickle Mutation in Human Adult Hematopoietic Stem/Progenitor Cells,” Science Translational Medicine 8, (2016): 360ra134, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500303/.
4. Mark DeWitt, phone interview, July 2, 2019.
5. He Jiankui, “The safety of gene-editing of human embryos to be resolved,” Science Net (blog), February 19, 2017, http://blog.sciencenet.cn/home.php?mod=space&uid=514529&do=blog&id=1034671.
6. George Church, “Future, Human, Nature: Reading, Writing, Revolution,” IGI, January 26, 2017, last viewed June 30, 2020, https://vimeo.com/209623759.
7. J. Benjamin Hurlbut, “Imperatives of Governance: Human Genome Editing and the Problem of Progress,” Perspectives in Biology and Medicine 63, (2020): 177–194, https://muse.jhu.edu/article/748059.
8. Ibid.
9. Preetika Ran, Amy Dockser Marcus, and Wenxin Fan, “China, unhampered by rules, races ahead in gene-editing trials,” Wall Street Journal, January 21, 2018, https://www.wsj.com/articles/china-unhampered-by-rules-races-ahead-in-gene-editing-trials-1516562360.
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12. L. Tang et al., “CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein,” Molecular Genetics and Genomics 292, (2017): 525–533, https://link.springer.com/article/10.1007%2Fs00438-017-1299-z.
13. G. Li et al., “Highly efficient and precise base editing in discarded human tripronuclear embryos,” Protein & Cell 8, (2017): 776–779, https://link.springer.com/article/10.1007/s13238-017-0458-7.
14. P. Liang et al., “Correction of B-thalassemia mutant by base editor in human embryos,” Protein & Cell 8, (2017): 811–822, https://link.springer.com/article/10.1007/s13238-017-0475-6.
15. C. Zhou et al., “Highly efficient base editing in human triplonuclear zygotes,” Protein & Cell 8, (2017): 772–775, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636752/.
16. L. Tang et al., “Highly efficient ssODN-mediated homology-directed repair of DBSs generated by CRISPR/Cas9 in human 3PN zygotes,” Molecular Reproduction and Development 85, (2018): 461–463, https://onlinelibrary.wiley.com/doi/abs/10.1002/mrd.22983.
17. Y. Zeng et al., “Correction of the Marfan syndrome pathogenic FBN1 mutation by base editing in human cells and heterozygous embryos,” Molecular Therapy 26, 2631–2637, https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(18)30378-2.
18. K. S. Bosley et al., “CRISPR-Germline Editing—The Community Speaks,” Nature Biotechnology 33, (2015): 478–486, https://www.nature.com/articles/nbt.3227.
19. Kathy Niakan, “Human embryo genome editing license,” The Francis Crick Institute, https://www.crick.ac.uk/research/labs/kathy-niakan/human-embryo-genome-editing-licence.
20. N. M. E. Fogarty et al., “Genome editing reveals a role for OCT4 in human embryogenesis,” Nature 550, (2017): 67–73, https://www.nature.com/articles/nature24033.
21. Steve Connor, “First human embryos edited in U.S.,” MIT Technology Review, July 26, 2017, https://www.technologyreview.com/s/608350/first-human-embryos-edited-in-us/.