Gitschier, Jane, 349
“Giving Genetic Disease the Finger,” 116
GJB2, 270
GlaxoSmithKline, 145
Global Blood Therapeutics, 155
“Golden Promise,” 303–304
Goldman, John, 298
Gonzales, Karine, 60
Goodale, Hubert, 123–124
Google, 95
Gootenberg, Jonathan, 100
Gorbachev, Mikhail, 108
Gorner, Peter, 137
Gosling, Raymond, 125
Gottlieb, Scott, 239, 264
GP-Write (Genome Project-Write), 281
Gray, Sarah, 255
Gray, Thomas, 143
Gray, Victoria, xvi, 169, 170, 172
Great Ormond Street Hospital, 163
Greely, Hank, 21, 188, 196, 222, 245, 253, 352–353
Green Revolution, 303, 319–320
Gregory, Philip, 111, 115
Greider, Carol, 183
Gretzky, Walter, 196
Gretzky, Wayne, 196
Groundhog Day, 191
Guangzhou Medical School, 222
Guardino, Christian, 147–148
Guggenheim Foundation, xvii
Guinness World Record, xv
Gupta, Sanjay, 12
Guschin, Dmitry, 111
Gusella, Jim, 49
Guthrie heel-stick test, 337
Gutterson, Neal, 314
H
Haas, Corey, 150
Hadassah Hospital, 136
Haidt, Jonathan, 315
Halcyon, 280
Hall, Stephen, 345
Haloferax species, 31–33
Hamburg, Margaret, 258
Hamilton, Jennifer, 365
Handyside, Alan, 339
Hanks, Tom, 166
Hansen, Egan Beck, 44
Haoyi, Wang, 275–276
Happiness Hypothesis, The, 315
“Happy,” 96
Harald V, King, 9
Harari, Yuval Noah, 191
Harmonicare Shenzhen Women and Children’s Hospital, 201
Harper, Joyce, 252
Harrington, Lucas, 100
Harris, John, 255, 359
Harrison, Patrick, 29
Harrison, Sean, 249
Harvard Medical School, xii, 15
Harvard University, xii, 15, 48, 70, 76–80, 85–91, 96–97, 101–102, 107, 148, 171, 233, 236, 265, 274, 279, 291, 295, 323–324, 351, 353, 355, 366
Haurwitz, Rachel, 53, 56, 173, 174
Hawking, Stephen, 7, 15–16, 97
“He Jiankui and Michael Deem Joint Laboratory,” 209
Health, Education, Labor and Pensions (HELP), 10–11
Heart disease, xi, xii, xiv, 223, 331, 345, 350, 351
Helicos, 208, 212
Hematopoietic stem cell (HSC), 157–158, 168
Hemmes, Don, 48
Hemochromatosis, 90, 329
Hemophilia, xviii, 114, 120, 136, 164
Henner, Marilu, 343
Hereditary persistence of fetal hemoglobin (HPFH), 156–157
Heritable genome editing, xvii, 228, 257, 362. See also Genome editing; Germline
“Heroes of CRISPR,” 92, 272
Herper, Matthew, 89
Herrick, James, 154
Hershey, Alfred, 109
High, Katherine, 149
Highly superior autobiographical memory (HSAM), 343
HIV, 5, 105, 116–119, 122, 146, 173, 199–202, 215–216, 225–228, 232–236, 244–251, 261–262, 269, 344
Ho, Teresa, 178
Hobbs, Helen, 345
Hockfield, Susan, 303, 304
Hoffman Foundation, 127
Holdaway, Isabelle, 163
Holdren, John, 255–256
Holiday, Billie, 96
Holmes, Elizabeth, 101, 206
Holmes, Michael, 111, 114–115
Holtzman, Neil, 354
Homo sapiens, 19, 67
Homologous recombination, 107–108
Homology Medicines, 336
Homology-directed repair (HDR), 29
Homozygotes, 115, 118
Hongwei, Meng, 242
Hood, 279
Hooke, Robert, 72
Horgan, Rich, 363
Horgan, Terry, 363
Horton, Richard, 257, 354, 358
Horvath, Philippe, 39–45, 54, 57, 69–71, 81–82, 95–97, 180
Hospital of the People’s Liberation Army, 266
Hotchkiss, Rollin, 127
How to Clone a Mammoth, 285
Howard Hughes Medical Institute (HHMI), 47, 53, 63, 74, 88, 285, 324, 364
Hsu, Stephen, 210, 350–352
Huanglongbing (HLB), 309–310
Huanming, Yang, 210
Hughes, Howard, 47
Hui, Yang, 275–276
Human CRISPR, 167
Human embryo experiments, ix–xi, 4–6, 14–15, 193–206, 211–229, 238, 243–246, 253–258, 261–276, 338–341, 348–355. See also In vitro fertilization
Human Fertilization & Embryology Authority (HFEA), 215, 222
Human Fertilization and Embryology Act, 214–215
Human Game, The, 196
Human genome editing, ix–x, 15–16, 220, 233, 256–258. See also Genome editing
Human Genome Ethics, 231
Human Genome Project (HGP)
announcement of, 234
impact of, 353
landmark in, 17
launching, 137–138
praise for, 91
role of, xi–xviii, 5
Human genome sequence. See also Genome sequencing
cracking, 18, 131, 362
impact of, xi
map of, 17, 18, 91
mutations and, 227–228
precision of, 112
Human Nature, 25
Hunt, Helen, 138
Hunt, Tim, 361
Hunter, Charles, 121
Hunter syndrome, 120–122, 193
Huntington’s disease, xi, 49, 122, 175, 322, 339, 350, 354
Hurlbut, Ben, 221, 247, 251, 268
Hurlbut, William, 220, 221, 227, 228, 243, 251, 259, 264
Hurler syndrome, 120
Hussein, Saddam, 37
Huxley, Aldous, 124, 233, 254–255, 341
Huxley, Julian, 341
Hyman, Steve, 91
Hynes, Rick, 256
Hypertension, 18, 345
Hyperthymesia, 343
Hysolli, Eriona, 284
I
“Illegal medical practice,” 264
Illnesses. See Diseases; Viruses
Illumina, 208, 209
Immerwahr, Werner Adolf Martin, 154
Immune system
bacterial immune system, xi–xii, 5, 36–38, 41–45, 50–61
components of, xi–xii, 5, 36–38
“defense mechanism,” 32, 38, 51, 63
viruses and, xi–xii, 38, 41–45, 50–61
Imperial College, 289
In vitro fertilization (IVF), 5, 14–15, 197, 202, 213–217, 222, 226, 229, 246, 258–262, 339–343, 351–356, 360, 363
Inception Genomics, 170
Independence Day, 118
Influenza, 101, 134, 142, 207, 249, 299, 318
Ingram, Vernon, 154–155
Innovative Genomics Institute (IGI), 105, 220, 221, 347, 364–365
Innovators, The, 279
Institute for Clinical and Economic Review, 160
Intel Science Talent Search, 77
Intellia Therapeutics, 13, 169, 173–175
International Data Group (IDG), 80
Iowa Methodist Medical Center, 77
Iowa State University, 304
IQ scores, 15, 129, 204, 343, 351–352, 357
Isaacson, Walter, 279
Ishino, Yoshizumi, 33
Iwasaki, Akiko, 366
J
Jackson, Peter, 166
Jackson-Grusby, Laurie, 85
Jacob, François, 58
Jacob, Howard, 194
Jaenisch, Rudy, 80
Jaffe, Sam, 116
James, Anthony, 293
Jansen, Ruud, 35
Jansen’s Foundation, 362–363
Jarvis, Lisa, 53
Jasin, Maria, 107–108, 114
Jaud, Jean-Paul, 313
Jeffreys, Alec, 92
Jenner, Edward, 218
Jenning, Charles, 91
Jeopardy, 179
Jian, Wang, 210–211, 266, 268
Jianguo, Zhao, 319
Jiankui, He, x–xi, xvii–xviii, 14–15, 193–212, 215–230, 232–276, 341–343, 347, 356. See also “JK”
Jihua, Qianren, 227
Jínek, Martin, 51–54, 64–66, 70–74, 87, 94, 97–98, 173, 180
Jinzhou, Qin, 194, 201, 264
“JK,” 193–212, 215–230, 232–276, 341–343, 356. See also Jiankui, He
Jobs, Steve, 195, 279
Johns Hopkins University, 11, 112, 173, 304, 321, 325
Johnson, Dwayne “The Rock,” ix, 244
Johnson, Emmanuel “Manny,” Jr., 157–158
Johnson, Lyndon, 128
Jones, Steve, 321
Joung, Keith, 87, 171, 272, 308, 329
Journal of Bacteriology, 38
Journal of the American Medical Association (JAMA), 154, 263