I am curious how niopo would act on people like us. Should a niopo session one day come to pass, then we should on no account send our wives away, as on that early spring reverie [The LSD trip of February 1951 is meant here.], that they may bind us fast if necessary....
Chemical analysis of this drug led to isolation of active principles that, like the ergot alkaloids and psilocybin, belong to the group of indole alkaloids, but which were already described in the technical literature, and were therefore not investigated further in the Sandoz laboratories. [Translator's note: The active principles of niopo are DMT (N,N-dimethyltryptamine) and its congeners. DMT was first prepared in 1931 by Manske.] The fantastic effects described above appeared to occur only with the particular manner of use as snuff powder, and also seemed to be related, in all probability, to the psychic structure of the Indian tribes concerned.
Ambivalence of Drug Use
Fundamental questions of drug problems were dealt with in the following correspondence.
Bottmingen, 16 December 1961
Dear Mr. Jünger,
On the one hand, I would have the great desire, besides the natural-scientific, chemical-pharmacological investigation of hallucinogenic substances, also to research their use as magic drugs in other regions.... On the other hand, I must admit that the fundamental question very much occupies me, whether the use of these types of drugs, namely of substances that so deeply affect our minds, could not indeed represent a forbidden transgression of limits. As long as any means or methods are used, which provide only an additional, newer aspect of reality, surely there is nothing to object to in such means; on the contrary, the experience and the knowledge of further facets of the reality only makes this reality ever more real to us. The question exists, however, whether the deeply affecting drugs under discussion here will in fact only open an additional window for our senses and perceptions, or whether the spectator himself, the core of his being, undergoes alterations. The latter would signify that something is altered that in my opinion should always remain intact. My concern is addressed to the question, whether the innermost core of our being is actually unimpeachable, and cannot become damaged by whatever happens in its material, physical-chemical, biological and psychic shells-or whether matter in the form of these drugs displays a potency that has the ability to attack the spiritual center of the personality, the self. The latter would have to be explained by the fact that the effect of magic drugs happens at the borderline where mind and matter merge-that these magic substances are themselves cracks in the infinite realm of matter, in which the depth of matter, its relationship with the mind, becomes particularly obvious. This could be expressed by a modification of the familiar words of Goethe:
"Were the eye not sunny,
It could never behold the sun;
If the power of the mind were not in matter,
How could matter disturb the mind."
This would correspond to cracks which the radioactive substances constitute in the periodic system of the elements, where the transition of matter into energy becomes manifest. Indeed, one must ask whether the production of atomic energy likewise represents a transgression of forbidden limits.
A further disquieting thought, which follows from the possibility of influencing the highest intellectual functions by traces of a substance, concerns free will.
The highly active psychotropic substances like LSD and psilocybin possess in their chemical structure a very close relationship with substances inherent in the body, which are found in the central nervous system and play an important role in the regulation of its functions. It is therefore conceivable that through some disturbance in the metabolism of the normal neurotransmitters, a compound like LSD or psilocybin is formed, which can determine and alter the character of the individual, his world view and his behavior. A trace of a substance, whose production or nonproduction we cannot control with our wills, has the power to shape our destiny. Such biochemical considerations could have led to the sentence that Gottfried Benn quoted in his essay "Provoziertes Leben"
[Provoked life]: "God is a substance, a drug!"
On the other hand, it is well known that substances like adrenaline, for example, are formed or set free in our organism by thoughts and emotions, which for their part determine the functions of the nervous system. One may therefore suppose that our material organism is susceptible to and shaped by our mind, in the same way that our intellectual essence is shaped by our biochemistry. Which came first can indeed no better be determined than the question, whether the chicken came before the egg.
In spite of my uncertainty with regard to the fundamental dangers that could lie in the use of hallucinogenic substances, I have continued investigations on the active principles of the Mexican magic morning glories, of which I wrote you briefly once before. In the seeds of this morning glory, that were called ololiuhqui by the ancient Aztecs, we found as active principles lysergic acid derivatives chemically very closely related to LSD. That was an almost unbelievable finding. I have all along had a particular love for the morning glories. They were the first flowers that I grew myself in my little child's garden. Their blue and red cups belong to the first memories of my childhood.
I recently read in a book by D. T. Suzuki, Zen and Japanese Culture, that the morning glory plays a great role in Japan, among the flower lovers, in literature, and in graphic arts. Its fleeting splendor has given the Japanese imagination rich stimulus. Among others, Suzuki quotes a three- line poem of the poetess Chiyo (1702-75), who one morning went to fetch water from a neighbor's house, because . . .
"My trough is captivated
by a morning glory blossom,
So I ask after water."
The morning glory thus shows both possible ways of influencing the mind-body-essence of man: in Mexico it exerts its effects in a chemical way as a magic drug, while in Japan it acts from the spiritual side, through the beauty of its flower cups.
Wilflingen, 17 December 1961
Dear Mr. Hofmann,
I give you my thanks for your detailed letter of 16 December. I have reflected on your central question, and may probably become occupied with it on the occasion of the revision of An der Zeitmauer [At the wall of time]. There I intimated that, in the field of physics as well as in the field of biology, we are beginning to develop procedures that are no longer to be understood as advances in the established sense, but that rather intervene in evolution and lead forth in the development of the species. Certainly I turn the glove inside out, for I suppose that it is a new world age, which begins to act evolutionarily on the prototypes. Our science with its theories and discoveries is therefore not the cause, rather one of the consequences of evolution, among others. Animals, plants, the atmosphere and the surfaces of planets will be concerned simultaneously. We do not progress from point to point, rather we cross over a line.