Moira nodded — not to say yes, but to say I understand your question. “There are different ways to do it, Julia. One way would indeed produce clones — all offspring genetically identical to the mother. This isn’t what we want. For one thing, it would not solve our basic problem — the lack of males.”
Camila’s hand went up. Moira, clearly annoyed by the interruption, blinked once, then nodded at her. “Is it really a problem?” Camila asked. “As long as we have the lab and can go on making more clones, would it really be such a bad thing to have a society with no males? At least for several generations?”
Moira silenced her with a gentle pushing movement of one hand. “That’s a question for later. There is another problem with this version of parthenogenesis, which is, again, that all offspring are the same. Exact copies. To get some genetic diversity, we need to use something called automictic parthenogenesis. Look, it’s a long story, but the point is that in normal sexual reproduction there is crossing over of chromosomes during meiosis. It’s a form of natural recombination of DNA. It’s what causes your children to look sort of like you, but not exactly like you. In the form of parthenogenesis that I am proposing to use, there would be that crossing over. An element of randomness.”
“And both boys and girls?” Dinah asked.
“That’s harder,” Moira admitted. “Synthesizing a Y chromosome is no joke. My prediction is that the first set of babies — perhaps the first few sets of them — will all be female. Because we simply need to get the population up. During that time I can be working on the Y chromosome problem. Later on, I hope that some little boys will result.”
“But these little girls — and later the boys — will still be made out of our own DNA?” Ivy asked.
“Yes.”
“So they’ll be quite similar to us genetically.”
“If I do nothing about it,” Moira said, “they’ll be like sisters. Perhaps even more similar than that implies. But there are a few tricks that I can use to create a wider range of genotypes out of the same source material. Perhaps they’ll be more like cousins. I don’t know, it’s never been tried.”
“Are we talking about the inbreeding problem? It sounds like it,” Dinah said.
“Loss of heterozygosity. Yes. I happen to know something about it. It’s why I was chosen as a member of the General Population.”
“Because of your work on black-footed ferrets and so on,” Ivy said.
“Yes. This is a closely analogous problem. But the point I would like you all to keep in mind is that we solved that problem in the case of the black-footed ferrets and we are going to solve it again.”
She said it with force and confidence that silenced the others for a few moments and left them looking at her for more.
Moira went on. “I think we all have at least an intuitive understanding of this, yes?”
That one was aimed at Julia, who looked mildly peeved, and bit off the following: “My daughter had Down syndrome. That is all I will say.”
Moira acknowledged it with a nod, then went on: “Everyone has some genetic defects. When you are breeding more or less randomly within a large population, there’s a tendency for those errors to be swamped by the law of averages. Everything sort of works out. But when two people sharing the same defect mate, their offspring is likely to have that defect as well, and over time we see the usual unpleasantness that we all associate in our minds with inbreeding.”
“So,” Luisa said, “if we follow the plan you have laid out, and begin, a few years down the road, with seven groups of what amount to siblings or cousins—”
“It’s not enough heterozygosity, to answer your question,” Moira said. “If you have a genetic predisposition to any disease, for example—”
“Alpha-thalassemia runs in my family,” Ivy said.
“That’s a fine example,” Moira returned. “As it happens, Old Earth compiled vast databases on such things before its destruction. All of which are in there now.” She gestured in the direction of her lab. “We have a very good idea which defects, on which chromosomes, are responsible for alpha-thalassemia. If you supply me with an ovum, I can find those defects and I can fix them before we begin parthenogenesis. Your offspring will be free of that defect. Barring some random future mutation, it’ll never return.”
Dinah raised her hand. “My brother was a carrier of cystic fibrosis. I haven’t been tested.”
Julia raised hers. “Three of my aunts died of the same form of breast cancer. I’ve been tested. I know I carry that defect as well.”
“The same answer applies in all of these cases,” Moira said. “If there’s a genetic test for it, then it means, by definition, that we know which defects are responsible for it. And knowing that, we can perform a repair.”
A new voice joined the conversation. “How about bipolar disorder?”
Everyone looked at Aïda.
She would live out the rest of her life, and go to meet her maker, without having a friend, or even a friendly conversation. So, no one was in a receptive frame of mind about her question. But the mere fact that she’d asked it suggested a level of introspection they hadn’t seen from her before. Moira considered it.
“I would have to do some research. I think that it does run in families to some extent. To the extent that it can be traced to particular locations on particular chromosomes, it can be treated like any other disease,” Moira said.
“Do you believe it should be?” Aïda asked.
Everyone looked automatically at Luisa, who nodded. “We are long past the point of thinking of mental illnesses as somehow a lesser kind of disease than physical. Such disorders should, in my opinion, be addressed in just the same way.”
“Do you believe it must be?”
Luisa colored slightly. “What is the point of these questions, Aïda?”
“I have done research on it,” Aïda said. “Some say that bipolarity is a useful adaptation. When things are bad, you become depressed, retreat, conserve energy. When things are good, you spring into action with great energy.”
“And your point is. .”
“Will you treat this condition in my offspring against my will? What if I want to have a lot of little bipolar kids?”
In the flustered silence that followed, Camila spoke. “What about aggression?”
Everyone turned to look at her, as if unsure they had heard her correctly.
“I’m serious,” she said. She looked toward Aïda. “I don’t mean to trivialize the suffering that your condition causes. But over the course of history, aggression has caused a far larger amount of pain and death than bipolar disorder or whatever. As long as we are fixing those aspects of the human psyche that lead to suffering, should we not eliminate the tendency to aggressive behavior?”
“That’s different,” Moira began. But she was interrupted by Dinah.
“Hold on a sec,” Dinah said. “I’m aggressive. I always have been. I was on track to be an Olympic soccer player! That’s the only way I’ve ever been able to amount to anything — by channeling my aggression into doing things.” She nodded across the table at Tekla. “Hell, look at her! How many times has she saved our asses by being aggressive?”
Tekla nodded. “Yes. Dinah saved me by taking aggressive action against rules of space station. Problem is not aggression. It is lack of discipline. A person can be aggressive”—she nodded at Dinah—“and still be constructive in society if she controls her passions.” And she threw a significant glare at Aïda, who let out a little snort and looked away.
“So you’re suggesting we breed people for discipline and self-control?” Ivy asked. “I’m not sure if I follow.”