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The mechanism by which discrete hereditary units, the genes, are reshuffled and passed on to the next generation, the way in which those genes are randomly altered, their molecular nature, and their wonderful ability to encode long chemical messages and replicate those messages precisely—all this was wholly unknown to Darwin. To attempt an understanding of the evolution of life when heredity was still an almost complete mystery would require either an exceptionally foolish or an exceptionally able scientist.

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Josiah Wedgwood and Erasmus Darwin had long entertained the hope that someday their children would formalize through marriage the bonds of affection that already united their two families. Of the two, only Erasmus lived to see it happen. His son, Robert, a generous but moody physician, a great big, fat man, a silhouette out of Dickens, who alternately comforted and terrified the patients of his far-flung practice, married Susannah Wedgwood. She was widely admired for her “gentle, sympathising nature” and the active role she took in her husband’s scientific interests. Susannah suffered an agonizing death from a gastrointestinal affliction out of sight but within earshot of her eight-year-old son, Charles. Writing near the end of his own life, he could recall nothing about his mother “except her death-bed, her black velvet gown, and her curiously constructed work-table.”

In this autobiographical memoir, conceived as a gift for his children and grandchildren, and written “as if I were a dead man in another world looking back at my own life,” Charles Darwin admitted “that in many ways I was a naughty boy … I was much given to inventing deliberate falsehoods, and this was always done for the sake of causing excitement.” He boasted to another boy that he “could produce variously coloured polyanthuses and primroses by watering them with certain coloured fluids, which was of course a monstrous fable.” Even at that tender age he had begun to speculate on the variability of plants. His life-long absorption in the natural world was under way. He became a passionate collector of the bits and pieces of Nature that form the gritty detritus in the pockets of children everywhere. He was particularly mad for beetles, but his sister convinced him that it would be immoral to take a beetle’s life merely for collecting. Dutifully, he confined himself to gathering up only the recently deceased. He watched the birds and recorded his observations of their behavior. “In my simplicity,” he later wrote, “I remember wondering why every gentleman did not become an ornithologist.”

At the age of nine he was sent to study at Dr. Butler’s day school. “Nothing could have been worse for the development of my mind,” Darwin later wrote. Butler believed that school was no place for curiosity or excitement about learning. For that, Charles looked to a well-thumbed copy of Wonders of the World, and to the members of his family who patiently answered his many questions. As an old man he could still recall the delight he felt when an uncle had explained to him how the barometer works. His older brother, Erasmus—named after their grandfather—transformed the garden toolhouse into a chemistry lab and allowed Charles to help him with his experiments. This earned Charles the nickname “Gas” at school and an angry public rebuke from Dr Butler.

Charles was doing so poorly at school that when it was time for Erasmus to go off to Edinburgh University, his father decided to send Charles with him. The boys were supposed to study medicine. Here, too, Charles found the lectures oppressively dull. He couldn’t bear to dissect anything, and the experience of seeing a botched operation on a child, “long before the blessed days of chloroform,” was to haunt him for the rest of his life. But it was in Edinburgh that he first found friends who shared his passion for science.

After two sessions at Edinburgh, Robert Darwin became resigned to the fact that Charles was not cut out for a medical career. Perhaps he would make a good clergyman? Dutiful Charles had no objections, but just the same, he thought he should check up on Church of England dogma before agreeing to commit his life to instilling it in others. “Accordingly I read with care Pearson on the Creed, and a few other books on divinity; and as I did not then in the least doubt the strict and literal truth of every word in the Bible, I soon persuaded myself that our Creed must be fully accepted.”

Charles spent the next three years at Cambridge University, where he managed to get better grades. But still he felt a restless dissatisfaction with the curriculum. His happiest moments there were spent in pursuit of his adored beetles, now dead or alive.I will give a proof of my zeaclass="underline" one day, on tearing off some old bark, I saw two rare beetles, and seized one in each hand; then I saw a third and new kind, which I could not bear to lose, so that I popped the one which I held in my right hand into my mouth. Alas! it ejected some intensely acrid fluid, which burnt my tongue so that I was forced to spit the beetle out, which was lost, as was the third one.

It was as a beetle hunter that the first published reference to Charles Darwin was made. “No poet ever felt more delighted at seeing his first poem published than I did at seeing, in Stephen’s Illustrations of British Insects, the magic words, ‘captured by C. Darwin, Esq.’ ”

At Cambridge he had been persuaded to take a course in geology taught by Adam Sedgwick. Darwin told Professor Sedgwick of the curious but credible claim made to him by a laborer that a “large, worn tropical Volute shell” (the spiral-shaped shell of a warm-water mollusc) had been found embedded in an old Shrewsbury gravel pit. Sedgwick was incurious and dismissive; it must have been dumped there by someone. Darwin remembered in his Autobiography,But then, [Sedgwick added,] if [the shell was] really embedded there it would be the greatest misfortune for geology, as it would overthrow all that we know about the superficial deposits of the Midland Counties. These gravel-beds belong in fact to the glacial period, and in after years I found in them broken arctic shells. But I was then utterly astonished at Sedgwick not being delighted at so wonderful a fact as a tropical shell being found near the surface in the middle of England. Nothing before had ever made me thoroughly realise, though I had read various scientific books, that science consists in grouping facts so that general laws or conclusions may be drawn from them.

At about that time, Darwin’s cousin brought him around to one of the Rev. John Steven Henslow’s botany lectures. This was “a circumstance which influenced my career more than any other.” A handsome man in his early thirties, Henslow had the great teacher’s genius for making his subject come alive, so much so that the same students returned year after year to attend courses they had already completed. Moreover, he exhibited an exceptional sensitivity to the feelings of his students. The novice’s “foolish” question was answered with respect. All were welcome to the open house he held every week, and there were regular invitations to dinner with his family. Darwin wrote, “during the latter half of my time at Cambridge I took long walks with him on most days; so that I was called by some of the dons ‘the man who walks with Henslow.’ ” Darwin judged his knowledge “great in botany, entomology, chemistry, mineralogy, and geology.” He added that Henslow was “deeply religious, and so orthodox that he told me one day he should be grieved if a single word of the Thirty-nine Articles [of the Anglican faith] were altered.”