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Their waiter caught up to them on the sidewalk.

“You left this.”

Alice paused, trying to comprehend how their waiter might come to possess her BlackBerry. She hadn’t checked her email or calendar in the restaurant. She felt inside her bag. No BlackBerry. She must’ve removed it when she fished her wallet out to pay.

“Thank you.”

Lydia looked at her quizzically, as if she wanted to say something about something other than food or weather, but then didn’t. They walked back to her apartment in silence.

“JOHN?”

Alice waited, suspended in the front hallway, holding the handle of her suitcase. Harvard Magazine lay on the top of a pile of unclaimed mail strewn on the floor in front of her. The clock in the living room ticked and the refrigerator hummed. A warm, sunny late afternoon at her back, the air inside felt chilly, dim, and stale. Uninhabited.

She picked up the mail and walked into the kitchen, her suitcase on wheels accompanying her like a loyal pet. Her flight had been delayed, and she was late getting in, even according to the microwave. He’d had a whole day, a whole Saturday, to work.

The red voice-mail light on their answering machine stared her down, unblinking. She checked the refrigerator. No note on the door. Nothing.

Still clutching the handle of her suitcase, she stood in the dark kitchen and watched several minutes advance on the microwave. The disappointed but forgiving voice in her head faded to a whisper as the volume of a more primal one began to build and spread out. She thought about calling him, but the expanding voice rejected the suggestion outright and refused all excuses. She thought about deciding not to care, but the voice, now seeping down into her body, echoing in her belly, vibrating in each of her fingertips, was too powerful and pervasive to ignore.

Why did it bother her so much? He was in the middle of an experiment and couldn’t leave it to come home. She’d certainly been in his shoes innumerable times. This was what they did. This was who they were. The voice called her a stupid fool.

She spotted her running shoes on the floor next to the back door. A run would make her feel better. That was what she needed.

Ideally, she ran every day. For many years now, she’d treated running like eating or sleeping, as a vital daily necessity, and she’d been known to squeeze in a jog at midnight or in the middle of a blinding snowstorm. But she’d neglected this basic need over the last several months. She’d been so busy. As she laced her shoes, she told herself she hadn’t bothered bringing them with her to California because she’d known she wouldn’t have the time. In truth, she’d simply forgotten to pack them.

When starting from her house on Poplar Street, she invariably followed the same route—down Massachusetts Avenue, through Harvard Square to Memorial Drive, along the Charles River to the Harvard Bridge over by MIT, and back—a little over five miles, a forty-five-minute round trip. She had long been attracted to the idea of running in the Boston Marathon but each year decided that she realistically didn’t have the time to train for that kind of distance. Maybe someday she would. In excellent physical condition for a woman her age, she imagined running strong well into her sixties.

Clustered pedestrian traffic on the sidewalks and intermittent negotiations with car traffic in street intersections littered the first part of her run through Harvard Square. It was crowded and ripe with anticipation at that time of day on a Saturday, with crowds forming and milling around on street corners waiting for walk signals, outside restaurants waiting for tables, in movie theater lines waiting for tickets, and in double-parked cars waiting for an unlikely opening in a metered space. The first ten minutes of her run required a good deal of conscious external concentration to navigate through it all, but once she crossed Memorial Drive to the Charles River, she was free to run in full stride and completely in the zone.

A comfortable and cloudless evening invited a lot of activity along the Charles, yet the grassy area beside the river felt less congested than the streets of Cambridge. Despite a steady stream of joggers, dogs and their owners, walkers, Rollerbladers, cyclists, and women pushing babies in jogger strollers, like an experienced driver on a regularly traveled stretch of road, Alice retained only a vague sense for what went on around her now. As she ran along the river, she became mindful of nothing but the sounds of her Nikes hitting the pavement in syncopated rhythm with the pace of her breath. She didn’t replay her argument with Lydia. She didn’t acknowledge her growling stomach. She didn’t think about John. She just ran.

As was her routine, she stopped running once she made it back to the John Fitzgerald Kennedy Park, a pocket of manicured lawns abutting Memorial Drive. Her head cleared, her body relaxed and rejuvenated, she began walking home. The JFK Park funneled into Harvard Square through a pleasant, bench-lined corridor between the Charles Hotel and the Kennedy School of Government.

At the other end of the corridor, she stood at the intersection of Eliot Street and Brattle, ready to cross, when a woman grabbed her forearm with startling force and said, “Have you thought about heaven today?”

The woman fixed Alice with a penetrating, unwavering stare. She had long hair the color and texture of a teased Brillo pad and wore a handmade placard hung over her chest that read AMERICA REPENT, TURN TO JESUS FROM SIN. There was always someone selling God in Harvard Square, but Alice had never been singled out so directly and intimately before.

“Sorry,” she said and, noticing a break in the flow of traffic, escaped to the other side of the street.

She wanted to continue walking but stood frozen instead. She didn’t know where she was. She looked back across the street. The Brillo-haired woman pursued another sinner down the corridor. The corridor, the hotel, the stores, the illogically meandering streets. She knew she was in Harvard Square, but she didn’t know which way was home.

She tried again, more specifically. The Harvard Square Hotel, Eastern Mountain Sports, Dickson Bros. Hardware, Mount Auburn Street. She knew all of these places—this square had been her stomping ground for over twenty-five years—but they somehow didn’t fit into a mental map that told her where she lived relative to them. A black-and-white circular “T” sign directly in front of her marked an entrance to the Red Line trains and buses underground, but there were three such entrances in Harvard Square, and she couldn’t piece together which one of the three this was.

Her heart began to race. She started sweating. She told herself that an accelerated heart rate and perspiration were part of an orchestrated and appropriate response to running. But as she stood on the sidewalk, it felt like panic.

She willed herself to walk another block and then another, her rubbery legs feeling like they might give way with each bewildered step. The Coop, Cardullo’s, the magazines on the corner, the Cambridge visitors’ center across the street, and Harvard Yard beyond that. She told herself she could still read and recognize. None of it helped. It all lacked a context.

People, cars, buses, and all kinds of unbearable noise rushed and wove around and past her. She closed her eyes. She listened to her own blood whoosh and pulse behind her ears.

“Please stop this,” she whispered.

She opened her eyes. Just as suddenly as it had left her, the landscape snapped snugly back into place. The Coop, Cardullo’s, Nini’s Corner, Harvard Yard. She automatically understood that she should turn left at the corner and head west on Mass Ave. She began to breathe easier, no longer bizarrely lost within a mile of home. But she’d just been bizarrely lost within a mile of home. She walked as fast as she could without running.

She turned onto her street, a quiet, tree-lined, residential road a couple of blocks removed from Mass Ave. With both feet on her road and her house in sight, she felt much safer, but not yet safe. She kept her eyes on her front door and her legs moving and promised herself that the sea of anxiety swelling furiously inside her would drain when she walked in the front hallway and saw John. If he was home.