The position of Philip was very disadvantageous. The eastern states, which ought to have acted in unison against all interference of Rome and probably under other circumstances would have so acted, had been mainly by Philip's fault so incensed at each other, that they were not inclined to hinder, or were inclined even to promote, the Roman invasion. Asia, the natural and most important ally of Philip, had been neglected by him, and was moreover prevented at first from active interference by being entangled in the quarrel with Egypt and the Syrian war. Egypt had an urgent interest in keeping the Roman fleet out of the eastern waters; even now an Egyptian embassy intimated at Rome very plainly, that the court of Alexandria was ready to relieve the Romans from the trouble of intervention in Attica. But the treaty for the partition of Egypt concluded between Asia and Macedonia threw that important state thoroughly into the arms of Rome, and compelled the cabinet of Alexandria to declare that it would only intermeddle in the affairs of European Greece with consent of the Romans. The Greek commercial cities, with Rhodes, Pergamus, and Byzantium at their head, were in a position similar, but of still greater perplexity. They would under other circumstances have beyond doubt done what they could to close the eastern seas against the Romans; but the cruel and destructive policy of conquest pursued by Philip had driven them to an unequal struggle, in which for their self-preservation they were obliged to use every effort to implicate the great Italian power. In Greece proper also the Roman envoys, who were commissioned to organize a second league against Philip there, found the way already substantially paved for them by the enemy. Of the anti-Macedonian party - the Spartans, Eleans, Athenians, and Aetolians - Philip might perhaps have gained the latter, for the peace of 548 had made a deep, and far from healed, breach in their friendly Alliance with Rome; but apart from the old differences which subsisted between Aetolia and Macedonia regarding the Thessalian towns withdrawn by Macedonia from the Aetolian confederacy - Echinus, Larissa Cremaste, Pharsalus, and Thebes in Phthiotis - the expulsion of the Aetolian garrisons from Lysimachia and Cius had produced fresh exasperation against Philip in the minds of the Aetolians. If they delayed to join the league against him, the chief reason doubtless was the ill-feeling that continued to prevail between them and the Romans.
It was a circumstance still more ominous, that even among the Greek states firmly attached to the interests of Macedonia - the Epirots, Acarnanians, Boeotians, and Achaeans - the Acarnanians and Boeotians alone stood steadfastly by Philip. With the Epirots the Roman envoys negotiated not without success; Amynander, king of the Athamanes, in particular closely attached himself to Rome. Even among the Achaeans, Philip had offended many by the murder of Aratus; while on the other hand he had thereby paved the way for a more free development of the confederacy. Under the leadership of Philopoemen (502-571, for the first time strategus in 546) it had reorganized its military system, recovered confidence in itself by successful conflicts with Sparta, and no longer blindly followed, as in the time of Aratus, the policy of Macedonia. The Achaean league, which had to expect neither profit nor immediate injury from the thirst of Philip for aggrandizement, alone in all Hellas looked at this war from an impartial and national-Hellenic point of view. It perceived - what there was no difficulty in perceiving - that the Hellenic nation was thereby surrendering itself to the Romans even before these wished or desired its surrender, and attempted accordingly to mediate between Philip and the Rhodians; but it was too late. The national patriotism, which had formerly terminated the federal war and had mainly contributed to bring about the first war between Macedonia and Rome, was extinguished the Achaean mediation remained fruitless, and in vain Philip visited the cities and islands to rekindle the zeal of the nation - its apathy was the Nemesis for Cius and Abydus. The Achaeans, as they could effect no change and were not disposed to render help to either party, remained neutral.
In the autumn of 554 the consul, Publius Sulpicius Galba, landed with his two legions and 1000 Numidian cavalry accompanied even by elephants derived from the spoils of Carthage, at Apollonia; on receiving accounts of which the king returned in haste from the Hellespont to Thessaly. But, owing partly to the far-advanced season, partly to the sickness of the Roman general, nothing was undertaken by land that year except a reconnaissance in force, in the course of which the townships in the vicinity, and in particular the Macedonian colony Antipatria, were occupied by the Romans. For the next year a joint attack on Macedonia was concerted with the northern barbarians, especially with Pleuratus, the then ruler of Scodra, and Bato, prince of the Dardani, who of course were eager to profit by the favourable opportunity.
More importance attached to the enterprises of the Roman fleet, which numbered 100 decked and 80 light vessels. While the rest of the ships took their station for the winter at Corcyra, a division under Gaius Claudius Cento proceeded to the Piraeeus to render assistance to the hard-pressed Athenians. But, as Cento found the Attic territory already sufficiently protected against the raids of the Corinthian garrison and the Macedonian corsairs, he sailed on and appeared suddenly before Chalcis in Euboea, the chief stronghold of Philip in Greece, where his magazines, stores of arms, and prisoners were kept, and where the commandant Sopater was far from expecting a Roman attack. The undefended walls were scaled, and the garrison was put to death; the prisoners were liberated and the stores were burnt; unfortunately, there was a want of troops to hold the important position. On receiving news of this invasion, Philip immediately in vehement indignation started from Demetrias in Thessaly for Chalcis, and when he found no trace of the enemy there save the scene of ruin, he went on to Athens to retaliate. But his attempt to surprise the city was a failure, and even the assault was in vain, greatly as the king exposed his life; the approach of Gaius Claudius from the Piraeeus, and of Attalus from Aegina, compelled him to depart. Philip still tarried for some time in Greece; but in a political and in a military point of view his successes were equally insignificant. In vain he tried to induce the Achaeans to take up arms in his behalf; and equally fruitless were his attacks on Eleusis and the Piraeeus, as well as a second attempt on Athens itself. Nothing remained for him but to gratify his natural exasperation in an unworthy manner by laying waste the country and destroying the trees of Academus, and then to return to the north.