No long time elapsed before the independence of the Galatians was expressly recognized and guaranteed by the senate. Eumenes determined to proceed to Rome in person, and to plead his cause in the senate. But the latter, as if troubled by an evil conscience, suddenly decreed that in future kings should not be allowed to come to Rome; and despatched a quaestor to meet him at Brundisium, to lay before him this decree of the senate, to ask him what he wanted, and to hint to him that they would be glad to see his speedy departure. The king was long silent; at length he said that he desired nothing farther, and re-embarked. He saw how matters stood: the epoch of half-powerful and half-free alliance was at an end; that of impotent subjection began.
Similar treatment befell the Rhodians. They had a singularly privileged position: their relation to Rome assumed the form not of symmachy properly so called, but of friendly equality; it did not prevent them from entering into alliances of any kind, and did not compel them to supply the Romans with a contingent on demand. This very circumstance was presumably the real reason why their good understanding with Rome had already for some time been impaired. The first dissensions with Rome had arisen in consequence of the rising of the Lycians, who were handed over to Rhodes after the defeat of Antiochus, against their oppressors who had (576) cruelly reduced them to slavery as revolted subjects; the Lycians, however, asserted that they were not subjects but allies of the Rhodians, and prevailed with this plea in the Roman senate, which was invited to settle the doubtful meaning of the instrument of peace. But in this result a justifiable sympathy with the victims of grievous oppression had perhaps the chief share; at least nothing further was done on the part of the Romans, who left this as well as other Hellenic quarrels to take their course. When the war with Perseus broke out, the Rhodians, like all other sensible Greeks, viewed it with regret, and blamed Eumenes in particular as the instigator of it, so that his festal embassy was not even permitted to be present at the festival of Helios in Rhodes. But this did not prevent them from adhering to Rome and keeping the Macedonian party, which existed in Rhodes as well as everywhere else, aloof from the helm of affairs. The permission given to them in 585 to export grain from Sicily shows the continuance of the good understanding with Rome. All of a sudden, shortly before the battle of Pydna, Rhodian envoys appeared at the Roman head-quarters and in the Roman senate, announcing that the Rhodians would no longer tolerate this war which was injurious to their Macedonian traffic and their revenue from port-dues, that they were disposed themselves to declare war against the party which should refuse to make peace, and that with this view they had already concluded an alliance with Crete and with the Asiatic cities. Many caprices are possible in a republic governed by primary assemblies; but this insane intervention of a commercial city - which can only have been resolved on after the fall of the pass of Tempe was known at Rhodes - requires special explanation. The key to it is furnished by the well-attested account that the consul Quintus Marcius, that master of the "new-fashioned diplomacy", had in the camp at Heracleum (and therefore after the occupation of the pass of Tempe) loaded the Rhodian envoy Agepolis with civilities and made an underhand request to him to mediate a peace. Republican wrongheadedness and vanity did the rest; the Rhodians fancied that the Romans had given themselves up as lost; they were eager to play the part of mediator among four great powers at once; communications were entered into with Perseus; Rhodian envoys with Macedonian sympathies said more than they should have said; and they were caught. The senate, which doubtless was itself for the most part unaware of those intrigues, heard the strange announcement, as may be conceived, with indignation, and was glad of the favourable opportunity to humble the haughty mercantile city. A warlike praetor went even so far as to propose to the people a declaration of war against Rhodes. In vain the Rhodian ambassadors repeatedly on their knees adjured the senate to think of the friendship of a hundred and forty years rather than of the one offence; in vain they sent the heads of the Macedonian party to the scaffold or to Rome; in vain they sent a massive wreath of gold in token of their gratitude for the non-declaration of war. The upright Cato indeed showed that strictly the Rhodians had committed no offence and asked whether the Romans were desirous to undertake the punishment of wishes and thoughts, and whether they could blame the nations for being apprehensive that Rome might allow herself all license if she had no longer any one to fear? His words and warnings were in vain. The senate deprived the Rhodians of their possessions on the mainland, which yielded a yearly produce of 120 talents (29,000 pounds). Still heavier were the blows aimed at the Rhodian commerce. The very prohibition of the import of salt to, and of the export of shipbuilding timber from, Macedonia appears to have been directed against Rhodes. Rhodian commerce was still more directly affected by the erection of the free port at Delos; the Rhodian customs-dues, which hitherto had produced 1,000,000 drachmae (41,000 pounds) annually, sank in a very brief period to 150,000 drachmae (6180 pounds). Generally, the Rhodians were paralyzed in their freedom of action and in their liberal and bold commercial policy, and the state began to languish. Even the alliance asked for was at first refused, and was only renewed in 590 after urgent entreaties. The equally guilty but powerless Cretans escaped with a sharp rebuke.
With Syria and Egypt the Romans could go to work more summarily. War had broken out between them; and Coelesyria and Palaestina formed once more the subject of dispute. According to the assertion of the Egyptians, those provinces had been ceded to Egypt on the marriage of the Syrian Cleopatra: this however the court of Babylon, which was in actual possession, disputed. Apparently the charging of her dowry on the taxes of the Coelesyrian cities gave occasion to the quarrel, and the Syrian side was in the right; the breaking out of the war was occasioned by the death of Cleopatra in 581, with which at latest the payments of revenue terminated. The war appears to have been begun by Egypt; but king Antiochus Epiphanes gladly embraced the opportunity of once more - and for the last time - endeavouring to achieve the traditional aim of the policy of the Seleucidae, the acquisition of Egypt, while the Romans were employed in Macedonia. Fortune seemed favourable to him. The king of Egypt at that time, Ptolemy VI, Philometor, the son of Cleopatra, had hardly passed the age of boyhood and had bad advisers; after a great victory on the Syro-Egyptian frontier Antiochus was able to advance into the territories of his nephew in the same year in which the legions landed in Greece (583), and soon had the person of the king in his power. Matters began to look as if Antiochus wished to possess himself of all Egypt in Philometor's name; Alexandria accordingly closed its gates against him, deposed Philometor, and nominated as king in his stead his younger brother, named Euergetes II, or the Fat. Disturbances in his own kingdom recalled the Syrian king from Egypt; when he returned, he found that the brothers had come to an understanding during his absence; and he then continued the war against both. Just as he lay before Alexandria, not long after the battle of Pydna (586), the Roman envoy Gaius Popillius, a harsh rude man, arrived, and intimated to him the command of the senate that he should restore all that he had conquered and should evacuate Egypt within a set term. Antiochus asked time for consideration; but the consular drew with his staff a circle round the king, and bade him declare his intentions before he stepped beyond the circle. Antiochus replied that he would comply; and marched off to his capital that he might there, in his character of "the god, the brilliant bringer of victory", celebrate in Roman fashion his conquest of Egypt and parody the triumph of Paullus.