Realizing the futility of trying to destroy mosquitos, Chagas devised ways to prevent mosquitos from coming into contact with malaria patients. He found that mosquitos ingest most parasites during the erythrocytic cycle, when merozoites abundantly attack the red blood cells. The erythrocytic cycle corresponds to parasitemia, characterized by high fever, which naturally attracts mosquitos. He advocated that these patients be quarantined in closed-off areas with walls, screens, ceilings, and caulked joints, as distant as possible from mosquitos. Moreover, Chagas treated patients with quinine to reduce fever and destroy parasites. Quinine is an Andean medicinal remedy for malarial fever from the bark of the Chinchona calasaya tree. Kallawaya herbalists have used it for centuries and brought it to workers of the Panama Canal (see Bastien 1987a).
Chagas devised a threefold program in Santos which became a protocol for malaria campaigns in other regions of Brazil by 1917. The approach consisted of 1) administration of quinine in dosages of 50 centigrams every three days, 2) isolation of patients from mosquitos in infirmaries with fine metal screens and continual treatment with quinine of other malarial patients in the region, and 3) periodic and systematic disinfecting of domiciles with pyrethrum. Chagas further contributed to malariology by describing the edematous form of Quartan fever (attacks occurring every fourth day), the bone-marrow lesions of malaria, and the description of the disease as a domiciliary infection, rarely contracted outdoors (Lewinsohn 1981:452).
Carlos Chagas succeeded against malaria primarily because he did fieldwork, observed the disease in its environment, and addressed the problem in a scientific and therapeutic way. He also worked with patients, parasites, and insects in epidemic settings to get an enlarged perspective of the disease. On returning to Rio from Santos, Chagas went to work on malaria control for the Xerem River dam and had similar success. In 1906 he became an associate of the Oswaldo Cruz Institute in Rio de Janeiro.
Railroad Stop at Lassance
At about the same time, Europeans and Brazilians intruded into the forests of Brazil to build a railroad connecting Rio de Janeiro with the northern city of Belem, near the mouth of the Amazon River. Indians, animals, insects, and parasites resisted the invaders, causing a standstill in Lassance, located on the banks of the Sâo Francisco River in Minas Gerais. Rail workers from Asia and Europe and slaves from Africa died by the thousands. In 1908, Estrada de Ferro Central do Brasil (the Central Railroad of Brazil) invited Carlos Chagas to come to Lassance.
Thirty-one years old, Carlos left his wife in Juiz de Fora, her native village, in December 1908. He traveled by train for twenty-four hours to Lassance, the end of the rail. Named after a French railroad engineer, Lassance had 1,500 people. African, Chinese, Irish, and Portuguese railroad workers lived in mobile encampments of boxcars fitted with bunks. Chagas was given one boxcar to serve as clinic, dormitory, and laboratory.
Lassance also had comfortable ranch homes and townhouses for the long-established Portuguese settlersmerchants, farmers, and rancherswho considered themselves a class apart. Socially positioned between the upper-class denizens and lower-class migrants were itinerant cowboys. The cowboys fought with each other and looked down upon the immigrants. The immigrants in particular suffered from the parasitic diseases of the tropics. They had not developed partial immunity, and many died from acute infections of parasitic diseases. (Partial immunity occurs when someone is already infected with parasites and usually will not suffer another acute attack because the parasites partially protect the host; this is the case with Chagas’ disease.)
Chagas had to treat the ailments of the people of Lassance. Parallel to the tracks lay the main street, Avenue Alfonso Pena, where the merchants, landowners, and authorities lived in townhouses, enclaves shut off from the bustle and dust of the street. Farther down were the infamously named streets, including Street of the Knife and Street of the Shot, all noted for their brothels, bars, and fights. Along these streets, merchants catered to the Brazilian cowboys, mixed breeds of blacks, Indians, and Portuguese, who herded cattle through Lassance while on the way to slaughterhouses in the southern cities of Curvelo and Belo Horizonte.
Carlos Chagas described Lassance years later to his son Carlos Chagas Filho (1988):
The village resembled the many movie versions of the settlement of the American West. The boisterous visitors considered me an “officer.” For several months none of those wounded during brawling (I could hear the shots in the distance) would come to the hospital I directed. After awhile, they came to me, and I treated their injuries.
Chagas treated the railroad workers so they could lay tracks. He treated them with arsenic for syphilis and quinine for malaria; he also advocated burning chrysanthemum to keep down the mosquitos. He employed a railroad car as a hospital and conducted research using another railway car as laboratory, clinic, and bedroom.
As Chagas treated the injured and diseased, he noticed that some symptoms were not from malaria. Like clockwork, the malarial parasite sporulates periodically with accompanying parasitemia (alternating chills and fevers). Latin Americans still refer to malaria as either M. quotidian (P. vivax causes paroxysms every twenty-four hours), M. tertian (P. falciparium causes paroxysms every forty-eight hours), and M. quartan (P. malariae causes paroxysms every four days). Chronic malaria also results in splenomegaly (enlargement of the spleen). Unlike malaria with its violent attacks, some Lassance patients suffered arrhythmias and other cardiac disorders which resulted in a sudden and nonviolent death.
At first, Chagas figured it was morbus gallicus (French disease), as syphilis was popularly called in Brazil, and treated the patients with arsenic. He wrote (Chagas Filho 1993:81):
Faced with an unknown disease, one usually thinks of syphilis, especially for railroad workers, undernourished, ravaged by malaria, victims of morbusgallicus, which usually accompanies those laying iron tracks. A population complaining about irregular heartbeats and atypical arrhythmias, indications of cardiac insufficiencies, and frequently leading to sudden death… inexplicable! Barbeiros/Vinchucas: Triatoma infestans
A clue was provided by an engineer who showed Carlos an arthropod insect known as a barbeiro or vinchuca (Triatoma infestans) that infested the barracks and sucked blood from the workers during the night. The workers complained that barbeiros bit them nocturnally, drew blood, and caused painful welts. The engineer inquired whether barbeiros as well as anopheles mosquitos spread malaria, and Chagas knew that anopheles mosquitos transmitted plasmodium parasites whose sexual reproductive cycle was limited to the gut of the mosquito. “Knowing the domiciliary habits of the insect, and its abundance in all the human habitations of the region,” Chagas (1922) wrote, “we immediately stayed on, interested in finding out the exact biology of the barbeiro, and the transmission of some parasite to man or to another vertebrate.”