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She tried to soothe herself enough to eat from the bowl of miso soup that steamed in front of her. It was no longer easy to do, this simple ritual of spoon to mouth that so many took for granted. She looked down at the swirl of soup and the fleshy gray squares floating in it and the smell nauseated her. She thought of hundreds of thousands eating Big Macs in their cars and dribbling mayonnaise down their fronts and wanted to scream.

Outside she watched a hummingbird flit to the feeder, tucking its long slender beak into an opening and darting away again. She had suction-cupped the feeder to the glass because she liked to watch them dance during the evenings, their nervous vibration of wings translated into a calming, fluid movement by the shadows of the trees in her backyard. Now that she could no longer play the piano without cramps in her hands, this was what beauty she had left.

A bit of a breeze made the shadows dance along in silent partnership, as beyond in the dusky light the multicolored flowers ducked and bobbed their heads. Soon they would be gone. It was fall, and they were dying too.

Next to her chair on the floor was the silver bowl. She kept it close to her because sometimes when the sickness rose up inside she couldn't make it to the bathroom in time. Lately there was blood. She kept a folded towel next to it that she could use to wipe her mouth, though she had not yet been able to do it today. The towel held a delicate lace pattern along its edge. Seemed like such a waste, dirtying a perfectly good towel on something so useless.

From where she sat she could see the dust beginning to gather on things--the tabletop, the picture frames on the shelf above the telephone, the windowpanes. For a long time she had fought the dust and then she had given up when the pain and dizziness had become too great. She had someone who would come in for a couple of hours a day to help her cook, but she would not hire a cleaning service to come in and vacuum and dust for her. In her mind that was a luxury reserved for single old men. It would be too much for her pride to bear.

She thought again, as she had countless times the past few months: / will not give up. I will not let it win.

Outside, the heads of the flowers dipped and turned like an audience at a play. The breeze was light and the air was warm. She thought about getting up and opening a window, but the idea of it overwhelmed her and she remained in her seat. Best to just sit and enjoy until she had gathered her strength for what was to come.

After twenty minutes she was ready to begin. She stood up, her swollen joints protesting loudly. She left the bowl of miso untouched, and walked slowly under the lovely carved-wood molding into the sitting room. She had cleared this room of all but a series of yoga mats in various bright colors and a low long table against the far wall, where she kept towels and bottled water at room temperature.

This was going to be a difficult session, she knew. But it was necessary to prepare. There would not be any more chances to do so, and she needed to be clear and focused for what lay ahead. She ground her molars together against the pain as she worked herself into the lotus position on a mat in the center of the room, and faced the bank of windows overlooking the patio.

The sun gently touched her face. She let the warmth wash over her, soothing her breathing until it became slow and deep. She folded her hands against her lap, her mind an empty shell, focused inward on her heartbeat. In a state of deep meditation she could slow that beat to less than fifty times per minute.

Tibetan Buddhism concerns itself with the power of the mind over the physical body. The belief is that everyone is linked, and everyone has the ability to influence the world through thought. A great Buddhist master had once said, "To study the Buddha Way is to study the self, to study the self is to forget the self, and to forget the self is to be enlightened by the ten thousand things." This was a goal Shelley had struggled to understand. She had studied the Dalai Lama's teachings very carefully. She had visited Tibet three separate times. She had hiked through mountain peaks in pursuit of enlightenment, of spiritual peace. But this riddle remained beyond her reach.

She worked in silence, stretching and loosening her body, calming her heart and mind. A sheen of sweat clung to her skin. She did not like the smell of sickness that came from it. She should not be noticing the smell at all, if she were successful in clearing her thoughts. But the impurities must work their way through her pores.

She imagined a war happening at the cellular level, white blood cells maturing as they were supposed to do, and moving as one to attack the blast cells and drive them out. This visualization was the important part. This was truly mind over matter.

When first diagnosed she had visited countless doctors, believing in the miracle of Western medicine. Many of them had been friends or colleagues. She had subjected herself to countless prodding and pokes and treatments. Nothing had worked; the leukemia had always returned, more aggressively than before. Finally she had begun to look elsewhere to find some kind of hope.

Physician, heal thyself. She had thought that true devotion would lead to inner peace, a journey that would lead to the loss of self that brought the elusive ten thousand things. She would learn to focus her mind into an efficient killing machine, eradicating the mutating cells as they swept through her blood. Through all this, she thought, she would be able to lose her fear. After all, what did anyone have to fear if the only truth was what the mind created? And the mind had the power to change everything?

But the fear was still there. In point of fact, it had grown, slowly eating her up inside like the cancer that ate away at her guts. It distracted her, kept her from focusing on what she must do. Perhaps, she thought, she was not truly devoted after all.

So she turned to something else.

From the very beginning she had tried to understand the truths of Lamaism in a different light. Everyone is linked, and everyone has the ability to influence the world through thought. She had come to believe this to be literally true. She had no doubt about what had happened to her. That night so many years ago she had felt something alien worm its way inside her body. Some kind of energy had been released that had forever altered her genetic makeup.

First chemotherapy had failed. Then the bone marrow transplant wouldn't take. Spirituality alone hadn't solved anything. As far and as wide as she had looked, there was no other option. So Jean Shelley had created one.

They still didn't know exactly how Sarah did it, but effect had something to do with electromagnetic energy. It seemed that whatever had caused her leukemia could cure it as well. At least, that had been Shelley's hope. And in fact, Sarah's strange power had put her into remission twice. Each time the cancer had returned, but already she had lived for six years longer than even the most optimistic doctors had predicted.

Both she and Evan had tried very hard to teach Sarah the importance of making amends for your mistakes. They had made real progress at first, until the fire. After that, they had lost her. She had come to hate all doctors, anyone who had anything to do with her life in the facility. In her mind, they had betrayed her. She had to be sedated every time Shelley was in the room, and then she had retreated deep inside herself.

Jean Shelley's death was coming. She had one last chance, but it was all getting so complicated now. She had worked so very hard to play everything just right, teasing Jess Chambers along, letting Evan think what he needed to think to be useful to her. What she had done could not be undone, all the long, complex plans she had put into motion, and everything was spiraling toward an end. It wouldn't be long before this last chance had passed beyond her reach.

The bell rang. The next scene in the last act. She closed her eyes and gathered her thoughts for a moment. She would have to give a command performance now, and she needed every ounce of energy she had left.