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With regard to your speaking in the Consistory, I think it would be best for the present while you are still so young, to refer whatever is proposed to you to His Holiness, giving as your reason your youth and inexperience. You will find that you will be asked to intercede with the Pope for many small objects. Try at first to do this as seldom as you can, and not to worry him unduly in this way. For it is the Pope’s nature to pay the most attention to those who bother him least… Farewell.

Lorenzo’s reference to Rome as a sink of iniquity was not unjust. There were reckoned to be almost seven thousand prostitutes in a population of less than 50,000, most of them working in brothels licensed by the papal authorities and many of them suffering from syphilis, ‘a kind of illness very common among priests’, according to Benvenuto Cellini, who caught the disease himself. There were almost as many professional criminals as prostitutes, many if not most of whom avoided punishment by paying bribes. There were alleged to be an average of fourteen murders a day; and although the stench from the rows of rotting corpses of executed men hanging from the battlements of the Castel Sant’ Angelo made it an ordeal to cross the bridge beneath, most murderers, if caught, were soon released. Roderigo Borgia, one of the richest cardinals, explained when asked why so many malefactors escaped execution, ‘The Lord requires not the death of a sinner, but rather that he may pay and live.’ It was this Roderigo Borgia who, on the death of Innocent VIII, secured his own succession as Alexander VI by disbursing the most lavish gifts to all his rivals and potential supporters. Five asses laden with gold were believed to have entered the courtyard of the one cardinal, Ascanio Sforza, whose own riches and influence might have defeated him.

The young cardinal Giovanni de’ Medici seems to have enjoyed his early years in Rome to the full; but once a price had been placed on his head by the government of Florence he thought it advisable to go abroad for a time. So, having obtained permission from Alexander to travel beyond the Alps, he left for Venice en route for Bavaria in company with his cousin Giulio, who had been studying at the university at Pisa. From Bavaria they went to Brussels, then travelled up to the Flemish coast with the intention of sailing for England. Changing their minds, they rode south for Rouen instead, then to Marseilles whence they took boat for Genoa to stay with Giovanni’s sister Maddalena. From Genoa, they returned at last to Rome where Alexander VI, having himself by then quarrelled with Florence, greeted them kindly.

They settled down in a palace in the city where, disregarding the meagreness of his resources, Giovanni determined to enjoy life to the full, surrounding himself with genial mends and a constant stream of guests. As well as his cousin Giulio, there lived in the palace Bernardo Dovizi da Bibbiena, brother to Piero Dovizi, a brilliant, amusing and wily man, five years older than Giovanni, formerly his tutor and soon to become his secretary. Often to be seen there also was Giovanni’s younger brother, Giuliano, a well-mannered, kind, rather feckless though not unambitious young man whose cheerful good nature had endeared him to the families of the Duke of Urbino and the Marquis of Mantua, his hosts during his years of exile. Another frequent guest was the Pope’s favourite nephew, Cardinal Galeotto Franciotto, whom Giovanni had at first chosen to cultivate for selfish reasons but whom he grew to love so much mat, after Franciotto’s early death; he could not hear his name mentioned without tears starting to his eyes.

With Franciotto on one side and Dovizi on the other, with Giuliano and Giulio, with various cardinals and visitors from Florence whose good opinion he was anxious to cultivate, and with numerous artists by whom the name of Medici was still revered, Giovanni played the part of host with such lavish generosity that he was frequently in debt His guests became used to the constant disappearance and reappearance of his most valuable pieces of silver, which made their way between his dining-room and the shops of the Roman pawnbrokers.

Yet although he spent long evenings at the dining-table, long mornings discussing the several arts in which he took a lively interest, and long afternoons hunting and hawking in the Campagna – explaining that such exercise, incongruous though it might be for a cardinal, was a necessary duty for one so corpulent – Giovanni was far from content to devote all his life to the pleasures he so obviously enjoyed. He seemed always to have one pale, short-sighted eye turned in the direction of the thin, bearded, restless figure of the newly elected Pope.

Julius II, who after the twenty-six-day Papacy of Alexander VI‘s successor, the decrepit Pius III, had been elected Pope in November 1503, was the grandson of a fisherman, a tall, handsome, rough, talkative, syphilitic, irascible man. He was much given to boasting of his poor childhood – when he had sailed with cargoes of onions down the Ligurian coast – of his lack of scholarship and of his taste for the life of a soldier. ‘I am no schoolman,’ he said once when asked to suggest a suitable emblem for a statue of him being made by Michelangelo. ‘Put a sword in my hand, not a book.’

Julius delighted in the sword. Not long after his elevation he set off, with twenty-four cardinals in unwilling attendance, to reduce the rebel cities of Perugia and Bologna whose obedience to the Church he was determined to compel. Shaken by the news of his approach, Gian-Paolo Baglioni, the ruler of Perugia, surrendered the city into his hands, kneeling before him and begging for mercy. The Pope forgave him but added, ‘Do it again and I’ll hang you.’ Then, leaving his cardinals no time for rest, he marched them through the marshes of the Romagna to Bologna. The city having been deserted by Giovanni Bentivoglio, they entered it on 11 November 1506, exhausted and peevish, their hands and faces red and lumpy with mosquito bites.

Having regained Bologna and Perugia for the Church, Julius now determined also to recover Rimini, Faenza and Ravenna, which had fallen into the hands of Venice. To do so he called into existence the League of Cambrai, allying himself not only with Louis of France and Ferdinand of Spain but also with the Emperor Maximilian who were all to take a share of the Venetian dominions. The combination was far too powerful for Venice whose troops were routed at Agnadello near Cremona on 14 May 1509. Yet the Pope, having so successfully extended the dominions of the Church, could not but regret that this had entailed foreign powers gaining footholds in Lombardy. He determined to drive diem out, repeatedly declaring, ‘I will not have these barbarians taking over Italy.’ He called upon all Italy to drive them back once more across the Alps, beginning with the French. ‘Let’s see,’ he said riding off to turn a French garrison out of Mirandola, ‘Let’s see who has the bigger balls, the King of France or I.’ Inspired by his relentless determination his troops captured Mirandola, through whose shattered walls he scrambled by means of a wooden scaling ladder. But it was to be many months before he was able to achieve a more significant success, for most Italian states, including Florence, showed little inclination to respond to his call.

France was the Florentines’ traditional friend. The friendship had, admittedly, been placed under severe strain by Charles VIII, but the war with Pisa which the French had provoked was now over. The Pisans had been forced to sue for peace after the defeat of their supporters, the Venetians, at Agnadello. The Florentines, therefore, decided to remain neutral – ‘a bad example’, the Pope declared angrily; but it was one which other Italian states thought it prudent to follow. So Julius, unable to rouse Italians by his call for a crusade against the French, turned to the Spaniards, now in firm possession of Naples. With them he formed a new Holy League whose forces marched north to Bologna which, having been retaken with French help by Alfonso d’Este, Duke of Ferrara, had been returned to Bentivoglio. At the same time, Julius announced that once Bologna had been recaptured his Legate there would be Cardinal Giovanni de’ Medici. Julius had been much impressed by Giovanni’s good-natured acceptance of the discomforts of campaigning and had already rewarded him with the see of Amalfi and the promise of further preferment. In Florence, the Signoria heard of Giovanni’s ascendance with alarm.