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What else? For my fiftieth birthday Connie bought me a beautiful racing bike that I sometimes ride along the leafy lanes, noting nature’s symphony and imagining what a collision with an HGV would do to my body. For my fifty-first, it was running gear, for my fifty-second, an ear- and nasal-hair trimmer, an object that continues both to appal and fascinate me, snickering away deep in my skull like a tiny lawnmower. The subtext of all these gifts was the same: do not stay still, try not to grow old, don’t take anything for granted.

Nevertheless, there’s no denying it; I am now middle-aged. I sit to put on socks, make a noise when I stand and have developed an unnerving awareness of my prostate gland, like a walnut clenched between my buttocks. I had always been led to believe that ageing was a slow and gradual process, the creep of a glacier. Now I realise that it happens in a rush, like snow falling off a roof.

By contrast, my wife at fifty-two years old seems to me just as attractive as the day I first met her. If I were to say this out loud, she would say, ‘Douglas, that’s just a line. No one prefers wrinkles, no one prefers grey.’ To which I’d reply, ‘But none of this is a surprise. I’ve been expecting to watch you grow older ever since we met. Why should it trouble me? It’s the face itself that I love, not that face at twenty-eight or thirty-four or forty-three. It’s that face.’

Perhaps she would have liked to hear this but I had never got around to saying it out loud. I had always presumed there would be time and now, sitting on the edge of the bed at four a.m., no longer listening out for burglars, it seemed that it might be too late.

‘How long have you—?’

‘A while now.’

‘So when will you—?’

‘I don’t know. Not any time soon, not until after Albie’s left home. After the summer. Autumn, the new year?’

Finally: ‘Can I ask why?’

4. b.c. and a.c.

For the question, and the ultimate answer, to make sense, some context might be necessary. Instinctively, I feel my life could be divided into two distinct parts — Before Connie and After Connie, and before I turn in detail to what happened that summer, it might be useful to give an account of how we met. This is a love story, after all. Certainly love comes into it.

5. the other ‘l’ word

‘Lonely’ is a troubling word and not one to be tossed around lightly. It makes people uncomfortable, summoning up as it does all kinds of harsher adjectives, like ‘sad’ or ‘strange’. I have always been well liked, I think, always well regarded and respected, but having few enemies is not the same as having many friends, and there was no denying that I was, if not ‘lonely’, more solitary than I’d hoped to be at that time.

For most people, their twenties represent some kind of high-water mark of gregariousness, as they embark on adventures in the real world, find a career, lead active and exciting social lives, fall in love, splash around in sex and drugs. I was aware of this going on around me. I knew about the nightclubs and the gallery openings, the gigs and the demonstrations; I noted the hangovers, the same clothes worn to work on consecutive days, the kisses on the tube and the tears in the canteen, but I observed it all as if through reinforced glass. I’m thinking specifically of the late eighties, which, for all their hardship and turmoil, seemed like a rather exciting time. Walls were coming down, both literally and figuratively; the political faces were changing. I hesitate to call it a revolution or portray it as some new dawn — there were wars in Europe and the Middle East, riots and economic turmoil — but there was at least a sense of unpredictability, a sense of change. I remember reading a great deal about a Second Summer of Love in the colour supplements. Too young for the First, I was completing my PhD — on Protein-RNA interactions and protein folding during translation — throughout the Second. ‘The only acid in this house,’ I was fond of saying around the lab, ‘is deoxyribonucleic acid’ — a joke that never quite got the acclaim it deserved.

Still, as the decade drew to a close things were clearly happening, albeit elsewhere and to other people, and I quietly wondered if a change was due in my life, too, and how I might bring that about.

6. drosophila melanogaster

The Berlin Wall was still standing when I moved to Balham. Approaching thirty, I was a doctor of biochemistry living in a small, semi-furnished, heavily mortgaged flat off the High Road, consumed by work and negative equity. I spent weekdays and much of the weekends studying the common fruit fly, Drosophila melanogaster, for my first post-doc, specifically using mutagens in classical forward genetic screens. Those were exciting times in Drosophila studies, developing the tools to read and manipulate the genomes of organisms and, professionally if not personally, this was something of a golden period for me.

I rarely encounter a fruit fly now, outside of a bowl of fruit. These days I work in the private, commercial sector — ‘the evil corporation’, my son calls it — as Head of Research and Development, a rather grand title but one that means I no longer experience the freedom and excitement of fundamental science. These days my position is organisational, strategical, words like that. We fund university research in order to make the most of academic expertise, innovation and enthusiasm, but everything must be ‘translational’ now; there must be some practical application. I enjoy the work, am good at it and I still visit labs, but now I am employed to co-ordinate and manage younger people who do the work that I used to do. I am not some corporate monster; I am good at my job and it has brought success and security. But it doesn’t thrill me like it used to.

Because it was thrilling, to be working all those hours with a small group of committed, impassioned people. Science seemed exhilarating to me then, inspiring and essential. Twenty years on, those experiments on fruit flies would lead to medical innovations that we could never have imagined, but at the time we were motivated by pure curiosity, almost by a sense of play. It was just terrific fun, and it would not be an exaggeration to say that I loved my subject.

That’s not to say there wasn’t a great deal of mundane graft involved, too; computers were temperamental and rudimentary, barely more than unwieldy calculators and considerably less powerful than the phone in my pocket now, and data input was exhausting and laborious. And while the common fruit fly has a great deal in its favour as an experimental organism — fecundity, a short breeding cycle, distinctive morphology — it has little in the way of personality. We kept one as a pet in our lab’s insectory, in its own special jar with a tiny rug and doll’s house furniture, replacing it at the end of each life cycle. Though it’s tricky to sex a fruit fly, we called him/her Bruce. Allow this to stand as the archetypal example of Biochemist Humour.

Such small diversions were necessary because anaesthetising a population of Drosophila, then examining them one by one with a fine brush and a microscope, looking for tiny changes in eye pigmentation or wing shape, is frankly mind-numbing. It’s a little like embarking on an immense jigsaw. To begin with you think ‘this will be fun’ and you put on the radio and make a pot of tea, before realising that there are far too many pieces, nearly all of them sky.

Consequently I was far too tired to go to my sister’s party on that Friday night. And not just tired, I was wary too, for a number of good reasons.

7. the matchmaker

I was wary of my sister’s cooking, which invariably consisted of a tubular pasta and economy cheese, charred black on the surface, with either tinned tuna or lardy mince lurking beneath the molten crust. I was wary because parties, and dinner parties in particular, had always seemed to be a pitiless form of gladiatorial combat, with laurel garlands bestowed to the most witty, successful and attractive, and the corpses of the defeated lying bleeding on the painted floorboards. The pressure to be one’s best self in such circumstances I found paralysing, and still do, yet my sister insisted on forcing me into the arena again and again.